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1

Airblast atomization at conditions of low air velocity

LEFEBVRE, A. H., KOBLISH, T. R., BECK, J. E.

Journal:

Journal of Propulsion and Power

Year:

1991

Language:

english

File:

PDF, 746 KB

english, 1991

2

Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists

Guo-Hua Chu, Christopher T. Saeui, Karin Worm, Damian G. Weaver, Allan J. Goodman, Robert L. Broadrup, Joel A. Cassel, Robert N. DeHaven, Christopher J. LaBuda, Michael Koblish, Bernice Brogdon, Steve

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 489 KB

english, 2009

3

Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

Grasberger, Bruce L., Lu, Tianbao, Schubert, Carsten, Parks, Daniel J., Carver, Theodore E., Koblish, Holly K., Cummings, Maxwell D., LaFrance, Louis V., Milkiewicz, Karen L., Calvo, Raul R.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 189 KB

english, 2005

4

[American Institute of Aeronautics and Astronautics 27th Aerospace Sciences Meeting - Reno,NV,U.S.A. (09 January 1989 - 12 January 1989)] 27th Aerospace Sciences Meeting - Airblast atomization at conditions of low air velocity

BECK, J., LEFEBVRE, A., KOBLISH, T.

Language:

english

File:

PDF, 430 KB

english

5

SAE Technical Paper Series [SAE International 1974 Automotive Engineering Congress and Exposition - (FEB. 25, 1974)] SAE Technical Paper Series - Design and Test Limitations on Reducing NOx in Gas Turbine Combustors

Breton, R. A., Koblish, T. R., Marshall, R. L.

Year:

1974

Language:

english

File:

PDF, 1.36 MB

english, 1974

6

The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: A new class of Aurora-A kinase inhibitors

Kevin J. Moriarty, Holly K. Koblish, Thomas Garrabrant, Jahanvi Maisuria, Ehab Khalil, Farah Ali, Ioanna P. Petrounia, Carl S. Crysler, Anna C. Maroney, Dana L. Johnson, Robert A. Galemmo Jr.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 360 KB

english, 2006

7

Novel malonamide derivatives as potent κ opioid receptor agonists

Guo-Hua Chu, Minghua Gu, Joel A. Cassel, Serge Belanger, Thomas M. Graczyk, Robert N. DeHaven, Nathalie Conway-James, Michael Koblish, Patrick J. Little, Diane L. DeHaven-Hudkins, Roland E. Dolle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 150 KB

english, 2007

8

Sulfamoyl benzamides as novel CB2 cannabinoid receptor ligands

Karin Worm, Q. Jean Zhou, Christopher T. Saeui, Rosalyn C. Green, Joel A. Cassel, Gabriel J. Stabley, Robert N. DeHaven, Nathalie Conway-James, Christopher J. LaBuda, Michael Koblish, Patrick J. Littl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 220 KB

english, 2008

9

Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain

Christopher J. LaBuda, Michael Koblish, Paul Tuthill, Roland E. Dolle, Patrick J. Little

Journal:

European Journal of Pain

Year:

2006

Language:

english

File:

PDF, 180 KB

english, 2006

10

Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists

Pierre Raboisson, Juan José Marugán, Carsten Schubert, Holly K. Koblish, Tianbao Lu, Shuyuan Zhao, Mark R. Player, Anna C. Maroney, Rolanda L. Reed, Norman D. Huebert, Jennifer Lattanze, Daniel J. Par

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 163 KB

english, 2005

11

Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints

Guo-Hua Chu, Minghua Gu, Joel A. Cassel, Serge Belanger, Thomas M. Graczyk, Robert N. DeHaven, Nathalie Conway-James, Mike Koblish, Patrick J. Little, Diane L. DeHaven-Hudkins, Roland E. Dolle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 166 KB

english, 2005

12

Novel phenylamino acetamide derivatives as potent and selective κ opioid receptor agonists

Guo-Hua Chu, Minghua Gu, Joel A. Cassel, Serge Belanger, Gabriel. J. Stabley, Robert N. DeHaven, Nathalie Conway-James, Mike Koblish, Patrick J. Little, Diane L. DeHaven-Hudkins, Roland E. Dolle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 112 KB

english, 2006

13

Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design

Daniel J. Parks, Louis V. LaFrance, Raul R. Calvo, Karen L. Milkiewicz, Juan José Marugán, Pierre Raboisson, Carsten Schubert, Holly K. Koblish, Shuyuan Zhao, Carol F. Franks, Jennifer Lattanze, Theod

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 346 KB

english, 2006

14

Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists

Juan Jose Marugan, Kristi Leonard, Pierre Raboisson, Joan M. Gushue, Raul Calvo, Holly K. Koblish, Jennifer Lattanze, Shuyuan Zhao, Maxwell D. Cummings, Mark R. Player, Carsten Schubert, Anna C. Maron

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 229 KB

english, 2006

15

Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity

Kristi Leonard, Juan Jose Marugan, Pierre Raboisson, Raul Calvo, Joan M. Gushue, Holly K. Koblish, Jennifer Lattanze, Shuyuan Zhao, Maxwell D. Cummings, Mark R. Player, Anna C. Maroney, Tianbao Lu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 153 KB

english, 2006

16

Azepinone as a conformational constraint in the design of κ-opioid receptor agonists

Paul A. Tuthill, Pamela R. Seida, William Barker, Joel A. Cassel, Serge Belanger, Robert N. DeHaven, Michael Koblish, Susan L. Gottshall, Patrick J. Little, Diane L. DeHaven-Hudkins, Roland E. Dolle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 371 KB

english, 2004

17

Synthesis and evaluation of novel peripherally restricted κ-opioid receptor agonists

Virendra Kumar, Deqi Guo, Joel A. Cassel, Jeffrey D. Daubert, Robert N. DeHaven, Diane L. DeHaven-Hudkins, Erin K. Gauntner, Susan L. Gottshall, Susan L. Greiner, Michael Koblish, Patrick J. Little, E

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 128 KB

english, 2005

18

Cannabinoid CB2 receptor agonist activity in the hindpaw incision: model of postoperative pain

Christopher J. LaBuda, Michael Koblish, Patrick J. Little

Journal:

European Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 178 KB

english, 2005

19

The creation of linear contiguous lesions in the atria with an expandable loop catheter

Boaz Avitall, Ray W Helms, Joseph B Koblish, Wayne Sieben, Alexey V Kotov, Gopal N Gupta

Journal:

Journal of the American College of Cardiology

Year:

1999

Language:

english

File:

PDF, 1.03 MB

english, 1999

20

Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N , N -Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

Bourdonnec, Bertrand Le, Windh, Rolf T., Ajello, Christopher W., Leister, Lara K., Gu, Minghua, Chu, Guo-Hua, Tuthill, Paul A., Barker, William M., Koblish, Michael, Wiant, Daniel D., Graczyk, Thomas

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 125 KB

english, 2008

21

Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9 R )-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain

Chen, Xiao-Tao, Pitis, Philip, Liu, Guodong, Yuan, Catherine, Gotchev, Dimitar, Cowan, Conrad L., Rominger, David H., Koblish, Michael, DeWire, Scott M., Crombie, Aimee L., Violin, Jonathan D., Yamash

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 873 KB

english, 2013

22

A G Protein-Biased Ligand at the -Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine

DeWire, S. M., Yamashita, D. S., Rominger, D. H., Liu, G., Cowan, C. L., Graczyk, T. M., Chen, X.-T., Pitis, P. M., Gotchev, D., Yuan, C., Koblish, M., Lark, M. W., Violin, J. D.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.12 MB

english, 2013

23

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

Journal:

Molecular Cancer Therapeutics

Year:

2006

Language:

english

File:

PDF, 307 KB

english, 2006

24

New RF J shaped catheter design for creation of circumferential linear lesions and PVs isolation

Avitall, Boaz, Aleksonis, Dinas, Koblish, Joseph, Chicos, Alexandru, Mykytsey, Andrew, Taimisto, Miriam

Journal:

Year:

2005

Language:

english

File:

PDF, 61 KB

english, 2005

25

An orally available mu-opioid receptor biased ligand is analgesic with reduced constipation in rodents

Violin, J., DeWire, S., Koblish, M., Chen, D., Crombie, A., Yamashita, D., Soergel, D., Lark, M.

Journal:

The Journal of Pain

Year:

2013

Language:

english

File:

PDF, 91 KB

english, 2013

26

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+T cells directly within the tumor microenvironment

Spranger, Stefani, Koblish, Holly K, Horton, Brendan, Scherle, Peggy A, Newton, Robert, Gajewski, Thomas F

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2014

Language:

english

File:

PDF, 321 KB

english, 2014

27

Hydroxyamidine Inhibitors of Indoleamine-2,3-dioxygenase Potently Suppress Systemic Tryptophan Catabolism and the Growth of IDO-Expressing Tumors

Koblish, H. K., Hansbury, M. J., Bowman, K. J., Yang, G., Neilan, C. L., Haley, P. J., Burn, T. C., Waeltz, P., Sparks, R. B., Yue, E. W., Combs, A. P., Scherle, P. A., Vaddi, K., Fridman, J. S.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 322 KB

english, 2010

28

Dihydroquinone Ansamycins: Toward Resolving the Conflict between Low in Vitro Affinity and High Cellular Potency of Geldanamycin Derivatives

Maroney, Anna C., Marugan, Juan J., Mezzasalma, Tara M., Barnakov, Alexander N., Garrabrant, Thomas A., Weaner, Larry E., Jones, William J., Barnakova, Ludmila A., Koblish, Holly K., Todd, Matthew J.,

Journal:

Year:

2006

Language:

english

File:

PDF, 98 KB

english, 2006

29

Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N , N -Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)

Le Bourdonnec, Bertrand, Windh, Rolf T., Leister, Lara K., Zhou, Q. Jean, Ajello, Christopher W., Gu, Minghua, Chu, Guo-Hua, Tuthill, Paul A., Barker, William M., Koblish, Michael, Wiant, Daniel D., G

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.65 MB

english, 2009

30

A Novel Kinase Inhibitor, INCB28060, Blocks c-MET-Dependent Signaling, Neoplastic Activities, and Cross-Talk with EGFR and HER-3

Liu, X., Wang, Q., Yang, G., Marando, C., Koblish, H. K., Hall, L. M., Fridman, J. S., Behshad, E., Wynn, R., Li, Y., Boer, J., Diamond, S., He, C., Xu, M., Zhuo, J., Yao, W., Newton, R. C., Scherle,

Journal:

Clinical Cancer Research

Year:

2011

Language:

english

File:

PDF, 910 KB

english, 2011

31

Immune Suppression by Recombinant Interleukin (rIL)-12 Involves Interferon Induction of Nitric Oxide Synthase 2 (iNOS) Activity: Inhibitors of NO Generation Reveal the Extent of rIL-12 Vaccine Adjuvant Effect

Koblish, H. K., Hunter, C. A., Wysocka, M., Trinchieri, G., Lee, W. M.F.

Journal:

Journal of Experimental Medicine

Year:

1998

Language:

english

File:

PDF, 123 KB

english, 1998

32

Innovative High-Temperature Aircraft Engine Fuel Nozzle Design

Stickles, R. W., Dodds, W. J., Koblish, T. R., Sager, J., Clouser, S.

Journal:

Journal of Engineering for Gas Turbines and Power

Year:

1993

Language:

english

File:

PDF, 2.11 MB

english, 1993

33

Maximal Electrogram Attenuation Recorded from Mini Electrodes Embedded on 4.5-mm Irrigated and 8-mm Nonirrigated Catheters Signifies Lesion Maturation

AVITALL, BOAZ, HORBAL, PIOTR, VANCE, DAVID, KOBLISH, JOSEF, KALINSKI, ARTHUR

Journal:

Journal of Cardiovascular Electrophysiology

Year:

2015

Language:

english

File:

PDF, 1.66 MB

english, 2015

34

Relationship between lesion formation and electrophysiological responses using catheters equipped with mini-electrodes in chronic atrial fibrillation

Avitall, Boaz, Kalinski, Arthur, Horbal, Piotr, Koblish, Josef

Journal:

Year:

2017

Language:

english

File:

PDF, 1.84 MB

english, 2017

35

[ASME ASME 1995 International Gas Turbine and Aeroengine Congress and Exposition - Houston, Texas, USA (Monday 5 June 1995)] Volume 3: Coal, Biomass and Alternative Fuels; Combustion and Fuels; Oil and Gas Applications; Cycle Innovations - Fuel Spray Characteristics of Gas Turbine Fuel Injectors at Cold Start Conditions

Koblish, Theodore R., Fox, Theodore G., Patel, Subhash G., Siddiqui, Jamil R.

Year:

1995

Language:

english

File:

PDF, 973 KB

english, 1995

36

[ASME ASME 1992 International Gas Turbine and Aeroengine Congress and Exposition - Cologne, Germany (Monday 1 June 1992)] Volume 3: Coal, Biomass and Alternative Fuels; Combustion and Fuels; Oil and Gas Applications; Cycle Innovations - Innovative High Temperature Aircraft Engine Fuel Nozzle Design

Stickles, R. W., Dodds, W. J., Koblish, T. R., Sager, J., Clouser, S.

Year:

1992

Language:

english

File:

PDF, 1.61 MB

english, 1992

37

TRV0109101, a G protein-biased agonist of the µ-opioid receptor, does not promote opioid-induced mechanical allodynia following chronic administration

Koblish, Michael, Carr, Richard, Siuda, Edward R, Rominger, David H, Gowen-MacDonald, William, Cowan, Conrad L, Crombie, Aimee L, Violin, Jonathan D, Lark, Michael W

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2017

Language:

english

File:

PDF, 666 KB

english, 2017

38

Pharmacological inactivation of PI3Kδ in the tumor microenvironment enhances efficacy of other immunotherapeutic agents

Wang, Liang-Chuan S, Koblish, Holly, Hansbury, Michael, Zhang, Yue, Yang, Gengjie, Burn, Timothy, Waeltz, Paul, Rupar, Mark, Yue, Eddy, Douty, Brent, Maduskuie, Thomas, Falahatpisheh, Nikoo, Li, Yun-L

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2015

Language:

english

File:

PDF, 247 KB

english, 2015

39

Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies

Koblish, Holly, Li, Yun-long, Shin, Niu, Hall, Leslie, Wang, Qian, Wang, Kathy, Covington, Maryanne, Marando, Cindy, Bowman, Kevin, Boer, Jason, Burke, Krista, Wynn, Richard, Margulis, Alex, Reuther,

Journal:

Year:

2018

Language:

english

File:

PDF, 2.20 MB

english, 2018

40

Treatment-induced tumor cell apoptosis and secondary necrosis drive tumor progression in the residual tumor microenvironment through MerTK and IDO-1

Werfel, Thomas A, Elion, David L, Rahman, Bushra, Hicks, Donna J, Sanchez, Violeta, Gonzalez-Ericsson, Paula I, Nixon, Mellissa J, James, Jamaal L, Balko, Justin M, Scherle, Peggy, Koblish, Holly K.,

Journal:

Cancer Research

Year:

2018

Language:

english

File:

PDF, 1.78 MB

english, 2018

41

Conformational sampling and kinetics changes across a non-Arrhenius break point in the enzyme thermolysin

Dong, Ming, Lauro, Mackenzie L., Koblish, Timothy J., Bahnson, Brian J.

Journal:

Structural Dynamics

Year:

2020

Language:

english

File:

PDF, 2.36 MB

english, 2020

42

Hematopoietic cytokines mediate resistance to targeted therapy in FLT3-ITD acute myeloid leukemia

Sung, Pamela J., Sugita, Mayumi, Koblish, Holly, Perl, Alexander E., Carroll, Martin

Journal:

Year:

2019

File:

PDF, 1.82 MB

2019

43

Characterization of human cancer xenografts in humanized mice

Rios-Doria, Jonathan, Stevens, Christina, Maddage, Christopher, Lasky, Kerri, Koblish, Holly K

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2020

File:

PDF, 2.03 MB

2020

44

INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models

Liu, Phillip C. C., Koblish, Holly, Wu, Liangxing, Bowman, Kevin, Diamond, Sharon, DiMatteo, Darlise, Zhang, Yue, Hansbury, Michael, Rupar, Mark, Wen, Xiaoming, Collier, Paul, Feldman, Patricia, Klabe

Journal:

Year:

2020

File:

PDF, 1.73 MB

2020

45

The pan-PIM inhibitor INCB053914 displays potent synergy in combination with ruxolitinib in models of MPN

Mazzacurati, Lucia, Collins, Robert J., Pandey, Garima, Lambert-Showers, Que T., Amin, Narmin E., Zhang, Ling, Stubbs, Matthew C., Epling-Burnette, Pearlie K., Koblish, Holly K., Reuther, Gary W.

Journal:

Year:

2019

File:

PDF, 1.39 MB

2019

46

Parsaclisib Is a Next-Generation PI3KÎ´ Inhibitor With Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy

Shin, Niu, Stubbs, Matthew, Koblish, Holly, Yue, Eddy W., Soloviev, Maxim, Douty, Brent, He Wang, Kathy, Wang, Qian, Gao, Mingming, Feldman, Patricia, Yang, Gengjie, Hall, Leslie, Hansbury, Michael, O

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2020

File:

PDF, 832 KB

2020